Central injection of L- and D-aspartate attenuates isolation-induced stress behavior in chicks possibly through different mechanisms

Edi Erwan, and Vishwajit Sur Chowdhury, and Mao Nagasawa, and Ryosei Goda, and Tsuyoshi Otsuka, and Shinobu Yasuo, and Mitsuhiro Furuse, (2014) Central injection of L- and D-aspartate attenuates isolation-induced stress behavior in chicks possibly through different mechanisms. European Journal of Pharmacology. pp. 138-142.

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Abstract

Intracerebroventricular (i.c.v.) injection of L- and D-aspartate (L- and D-Asp) has been shown to have a sedative effect with and without a hypnotic effect, respectively, in neonatal chicks experiencing isolation stress. However, the mechanisms of the different stress-attenuating functions of L- and D-Asp have not yet been fully clarified. In the present study, we investigated the involvement of the N-methyl-Daspartate (NMDA) receptor in order to reveal the receptor-mediated function of L- and D-Asp. To reveal whether L-and D-Asp act through the NMDA receptor, (þ)–MK-801, which is an antagonist of NMDA receptors, was used in the current study. In experiment 1, the chicks were injected i.c.v. with either saline, (þ)–MK-801, L-Asp or L-Asp plus (þ)–MK-801. The sedative and hypnotic effects induced by L-Asp were blocked by co-administration with (þ)–MK-801. In experiment 2, the chicks were injected i.c.v. with either saline, (þ)–MK-801, D-Asp or D-Asp plus (þ)–MK-801. Importantly, the sedative effects induced by D-Asp were shifted to hypnotic effects by co-administration with (þ)–MK-801. Taken together, L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but the attenuation of stress behaviors by D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor in this process. These differences may explain the different functional mechanisms of L- and D-Asp in the central nervous system.

Item Type: Article
Subjects: 600 Teknologi dan Ilmu-ilmu Terapan > 630 Usaha Tani, Pertanian, Teknologi Pertanian > 630.7 Pendidikan Pertanian, Riset Penelitian Pertanian
Divisions: Fakultas Pertanian dan Peternakan > Agroteknologi
Depositing User: Ari Eka Wahyudi
Date Deposited: 16 Apr 2019 04:03
Last Modified: 16 Apr 2019 04:03
URI: http://repository.uin-suska.ac.id/id/eprint/12759

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