Central administration of L- and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks

Edi Erwan, and Shozo Tomonaga, and Junki Yoshida, and Mao Nagasawa, and D. Michael Denbow, and Mitshhiro Furuse, (2012) Central administration of L- and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks. Springer.

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Abstract

Intracerebroventricular (i.c.v.) administration of L-aspartate (L-Asp) attenuates stress responses in neonatal chicks, but the mechanism has not been clarified. In the present study, three behavioral experiments were carried out under socially isolated stressful conditions exacerbated by the use of corticotrophin-releasing factor (CRF). In Experiment 1, i.c.v. injection of L-Asp attenuated behavioral stress responses (distress vocalization and active wakefulness) in a dose-dependent manner. Furthermore, L-Asp increased time spent standing/sitting motionless with eyes open and sitting motionless with head dropped (sleeping posture) in comparison with the group receiving CRF alone. In Experiment 2, i.c.v. injection of D-Asp dosedependently decreased the number of distress vocalizations and the amount of time spent in active wakefulness. D-Asp increased the time spent standing/sitting motionless with eyes open compared with the group receiving CRF alone. In Experiment 3, we directly compared the effect of L-Asp with that of D-Asp. Both L- and D-Asp induced sedative effects under an acutely stressful condition. However, L-Asp, but not D-Asp, increased the time spent in a sleeping posture. These results indicate that both L- and D-Asp, when present in the brain, could induce a sedative effect, while the mechanism for hypnosis in neonatal chicks may be different for L-Asp in comparison with D-Asp.

Item Type: Other
Subjects: 600 Teknologi dan Ilmu-ilmu Terapan > 630 Usaha Tani, Pertanian, Teknologi Pertanian > 630.7 Pendidikan Pertanian, Riset Penelitian Pertanian
Divisions: Fakultas Pertanian dan Peternakan > Agroteknologi
Depositing User: Ari Eka Wahyudi
Date Deposited: 15 Apr 2019 02:46
Last Modified: 15 Apr 2019 02:46
URI: http://repository.uin-suska.ac.id/id/eprint/12750

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